2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. E3 Ligase Ligand-Linker Conjugates Isoform

E3 Ligase Ligand-Linker Conjugates

 

E3 Ligase Ligand-Linker Conjugates Related Products (517):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145449
    CC-885-CH2-PEG1-NH-CH3 2722698-03-3 98.52%
    CC-885-CH2-PEG1-NH-CH3 is a neoDegrader that can be used in the synthesis of Antibody neoDegrader Conjugate (AnDC). CC-885-CH2-PEG1-NH-CH3 is the toxic molecule of ADC, which can specifically degrade the target protein in cancer cells through the E3 ubiquitin ligase pathway.
    CC-885-CH2-PEG1-NH-CH3
  • HY-145448
    MC-VC-PABC-amide-PEG1-CH2-CC-885 2722697-82-5 99.93%
    MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs).
    MC-VC-PABC-amide-PEG1-CH2-CC-885
  • HY-139218
    (S,R,S)-AHPC-Me-C6-NH2 2411422-49-4 99.81%
    (S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs.
    (S,R,S)-AHPC-Me-C6-NH2
  • HY-161128
    Lenalidomide 4'-PEG1-amine dihydrochloride 2624336-86-1 99.51%
    Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Lenalidomide 4'-PEG1-amine dihydrochloride
  • HY-131872
    Pomalidomide-PEG2-COOH 2140807-17-4 99.86%
    Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
    Pomalidomide-PEG2-COOH
  • HY-W877997
    Pomalidomide 5'-pip-acid 2467965-70-2 98.06%
    Pomalidomide 5'-pip-acid is an E3 ligase ligand-linker conjugate derived from the molecular glue Pomalidomide (HY-10984), which can be used to synthesize the dual-target PROTAC degrader PROTAC CBP/p300/BRD4 Degrader-1 (HY-181758) targeting CBP/p300 and BRD4. Pomalidomide 5'-pip-acid shows anti-proliferative activity against cancer cells with an IC50 of 2.73 nM. Pomalidomide 5'-pip-acid induces anti-proliferative effects in cancer cells. Pomalidomide 5'-pip-acid is applicable to research related to prostate cancer and colorectal cancer.
    Pomalidomide 5'-pip-acid
  • HY-W998278A
    Desamino lenalidomide-acetylene-C2-NH2 TFA 3065251-37-5
    Desamino lenalidomide-acetylene-C2-NH2 TFA is an E3 ligand-linker conjugate that incorporates a ligand based on CRBN and a linker, and can be used for the synthesis of PROTAC.
    Desamino lenalidomide-acetylene-C2-NH2 TFA
  • HY-403301
    (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH 2250056-22-3
    (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH is an E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH can be used for synthesis of PROTACs.
    (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH
  • HY-139345
    (S,R,S)-AHPC-CO-C9-acid 2172819-78-0
    (S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs.
    (S,R,S)-AHPC-CO-C9-acid
  • HY-148671
    (S,R,S)-AHPC-amido-C7-acid 2172819-76-8 98.71%
    (S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.
    (S,R,S)-AHPC-amido-C7-acid
  • HY-W854844A
    (E)-JP-2-196 TFA 3065021-33-9
    JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders.
    (E)-JP-2-196 TFA
  • HY-161129
    Lenalidomide 4'-PEG2-amine dihydrochloride 2624336-88-3 98.96%
    Lenalidomide 4'-PEG2-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Lenalidomide 4'-PEG2-amine dihydrochloride
  • HY-132208
    Pomalidomide 4'-PEG2-azide 2271036-45-2 98.03%
    Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide 4'-PEG2-azide
  • HY-169357B
    Acepromazine-1-piperazinepropanamine dihydrochloride 99.46%
    Acepromazine-1-piperazinepropanamine dihydrochloride (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. Acepromazine-1-piperazinepropanamine dihydrochloride can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355).
    Acepromazine-1-piperazinepropanamine dihydrochloride
  • HY-135045
    (S,R,S)-AHPC-C4-COOH 2172819-74-6
    (S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC.
    (S,R,S)-AHPC-C4-COOH
  • HY-133699
    Pomalidomide-PEG4-COOH 2138440-81-8 98.0%
    Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
    Pomalidomide-PEG4-COOH
  • HY-133139
    Lenalidomide-PEG1-azide 2185795-67-7
    Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136). Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Lenalidomide-PEG1-azide
  • HY-155262
    Pomalidomide-5-C6-NH2 hydrochloride 3007650-02-1 98.46%
    Pomalidomide-5-C6-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-C6-NH2 hydrochloride
  • HY-139339
    Pomalidomide 4'-alkylC6-azide 2375555-72-7 99.43%
    Pomalidomide 4'-alkylC6-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC6-azide can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide 4'-alkylC6-azide
  • HY-143348
    NJH-2-030 2709040-02-6 98.74%
    NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.
    NJH-2-030